Most keys fall under HKey_Users and HKey_Local_Machine. HKU should
be thought of as the user part of all configuration, while HKLM is the
computer part. Many settings that are per computer are looked at when the
computer boots, like settings for services, and are then never checked again.
A reboot forces all programs to check any changes in the machine section of
the registry. This is one of the reasons you may need to reboot, some others
may be because a file is locked during normal operation, and needs changed
during boot.
Some programs read data in the HKCU key on login, and never again.
When changed, these programs will generally tell you to reboot, but actually
a login is all that’s needed.
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